1,024 research outputs found
Guide to the use of Mariner images
Planetary imaging from unmanned spacecraft, almost exclusively done by digital systems, is examined. The Mars Mariner 9 television camera, representative of such systems, is considered. Each image consists of 700 lines, each containing 832 picture elements, or pixels. Each pixel contains nine binary bits of information capable of displaying 512 discrete brightness levels. Several problems inherent in television systems are discussed. These include nonuniform target response, residual images, noise, and blemishes. These defects can be removed to some extent by decalibration of the image. The final product is geometrically corrected for camera distortion and photometrically corrected. Several versions of the decalibrated images are available. The most generally useful are the geometrically corrected images with enhanced contrast. The Mariner 10 imaging of Mercury is briefly discussed
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Introduction [special issue: Critical realism in information systems research]
The Fibrinolysis Renaissance
Open Access via the Elsevier agreement Figures were created with BioRender.com and exported under a paid subscription.Peer reviewedPublisher PD
Let's cross-link: diverse functions of the promiscuous cellular transglutaminase factor XIII-A
Factor XIII is a tranglutaminase enzyme that catalyzes the formation of Īµā(Ī³āglutamyl)lysyl isopeptide bonds in protein substrates. The plasma form, FXIIIāA2B2, has an established function in hemostasis, where its primary substrate is fibrin. A deficiency in FXIII manifests as a severe bleeding diathesis, underscoring its importance in this pathway. The cellular form of the enzyme, a homodimer of the Aāsubunits, denoted FXIIIāA, has not been studied in as extensive detail. FXIIIāA was generally perceived to remain intracellular, owing to the lack of a classical signal peptide for its release. In the last decade, emerging evidence has revealed that this diverse transglutaminase can be externalized from cells, by an as yet unknown mechanism, and can crossālink extracellular substrates and participate in a number of diverse pathways. The FXIIIāA gene (F13A1) is expressed in cells of bone marrow and mesenchymal lineage, notably megakaryocytes, monocytes/macrophages, dendritic cells, chrondrocytes, osteoblasts, and preadipocytes. The biological processes that FXIIIāA is coupled with, such as wound healing, phagocytosis, and bone and matrix remodeling, reflect its expression in these cell types. This review describes the mounting evidence that this cellular transglutaminase can be externalized, usually in response to stimuli, and participate in extracellular crossālinking reactions. A corollary of being involved in these biological pathways is the participation of FXIIIāA in pathological processes. In conclusion, the functions of this transglutaminase extend far beyond its role in hemostasis, and our understanding of this enzyme in terms of its secretion, regulation and substrates is in its infancy
Novel aspects of platelet factor XIII function
Acknowledgments The study was supported by grants FS/11/2/28579 (N.J.M.) from the British Heart Foundation and the University of Aberdeen Development Trust.Peer reviewedPostprin
Sedimentary and Structural History of Narragansett Basin
Guidebook: 55th annual meeting, October 4-6, 1963, Providence, Rhode Island: Trip
Challenges for the development of surface modified biodegradable polyester biomaterials: a chemistry perspective
The design of current implants produced from biodegradable polyesters is based on strength and rate of degradation and tailored by the choice of polyester used. However, detailed knowledge about the degradation mechanism of surface modified materials with applications in biomaterials science and tissue engineering is currently lacking. This perspective aims to outline the need for a greater focus on analyzing the degradation of modified polyesters to ensure they can fulfil their intended function and that degradation products can effectively be cleared from the body. The status of the literature regarding surface modified polyesters is summarized to illustrate the main aspects investigated in recent studies and specifically the number of studies investigating the fate of the materials upon degradation. Published by the AVS
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